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Droplet-based Microfluidic Platform for Intracellular Ion Channel Drug Discovery

This project aims to produce and test a new microsystem technology to study human intracellular ion channels. Whilst developing this new technology in collaboration with our industrial partners, this study will investigate two proteins that are involved in cancer and neurodegeneration which currently have no known pharmacologically identified drug.

SP1.


Dr Yu Zhang

Co-Investigators:

Dr M. Zagnoni, Univ. Strathclyde

Dr C. Woolhead, Univ. Glasgow

Smartox

AstraZeneca


Vaccine delivery via high-throughput nanoparticle-enhanced cell imaging in microfluidic devices (Project concluded)

The aim of this project is to develop a novel system, combining microfluidics with nanomaterials and imaging tools, for screening nanoparticle-based vaccine candidates at the single cell level, creating a high-throughput technology that allows cell-nanoparticles interactions to be monitored in real-time. This technology will provide a novel platform that can be used for a variety of medical applications based on nanoparticle-drug delivery.

SP2.


Dr Carlota Cunha Matos

Co-Investigators:

Dr M. Zagnoni, Univ. Strathclyde

Dr A. Wark, Univ. Strathclyde

Dr O. Millington, Univ. Strathclyde


Improving cancer cell death using Raman spectroscopy and microfluidic technology

The aim of this project is to combine surface enhanced Raman scattering (SERS) with microfluidic technologies to produce a device capable of analysing specific cancer cells from tissue based on their vibrational fingerprint. This approach will aid understanding of  fundamental biological coping strategies to eradicate cancer cells and could be implicated in drug treatments of cancer.

SP3.


Jacob Melnyk

Co-Investigators:

Prof D. Graham, Univ. Strathclyde

Dr M. Zagnoni, Univ. Strathclyde



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