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Investigating drug effects on cancer cells using high-throughput microfluidic assays (Project concluded)

The aim of this project is to investigate the characteristics of emulsion-based techniques for the formation and long term culture of multicellular glioma cancer spheroids and apply these findings to assess the cytotoxic effect of X-ray radiation on spheroids. The microfluidics will allow the identification of the effects produced on the proliferative state of the spheroids due to the compartmentalised nature of the emulsions, creating a model that mimics tumour growth and tumour quiescence.

dropproj1.


Dr Kay McMillan

Co-Investigators:

Dr M. Zagnoni, Univ. Strathclyde

Dr M. Boyd, Univ. Strathclyde


3D micro-liver on a chip

The aim of this project is to develop a miniaturised technology to screen liver toxicity in vitro, using 3D hepatocyte structures. This is done using emulsion techniques that enable the long-term culture of primary liver cells to be obtained in 3D. Microfluidic procedures will be developed to create an in vitro model of liver tissue that mimics in vivo hepatic conditions and is able to predict formation of reactive intermediates from foreign compounds, e.g. candidate pharmaceuticals, which have the potential to cause toxicity in vivo.

DP2.


Myndert Claasen

Co-Investigators:

Dr M. Zagnoni, Univ. Strathclyde

Prof H. Grant, Univ. Strathclyde

Dr D. Watson, Univ. Strathclyde



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